201 DEGRADATION OF OPTICIN, A MEMBER OF THE SMALL LEUCINE-RICH REPEAT PROTEOGLYCANS FAMILY, BY METALLOPROTEASES AND ADAMTS INVOLVED IN OSTEOARTHRITIS
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چکیده
منابع مشابه
Correction: Degradation of small leucine-rich repeat proteoglycans by matrix metalloprotease 13 - identification of a new biglycan cleavage site
Author details 1Osteoarthritis Research Unit, University of Montreal Hospital Centre, NotreDame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec H2L 4M1, Canada. 2Department of Rheumatology, Universitat Autonoma de Barcelona, Hospital del Mar, Passeig Marítim de la Barceloneta, 25, 08005 Barcelona, Spain. 3Genetics Unit, Shriner’s Hospital for Children, 1529 Cedar Avenue, Montreal, Quebe...
متن کاملDegradation of small leucine-rich repeat proteoglycans by matrix metalloprotease-13: identification of a new biglycan cleavage site
A major and early feature of cartilage degeneration is proteoglycan breakdown. Matrix metalloprotease (MMP)-13 plays an important role in cartilage degradation in osteoarthritis (OA). This MMP, in addition to initiating collagen fibre cleavage, acts on several proteoglycans. One of the proteoglycan families, termed small leucine-rich proteoglycans (SLRPs), was found to be involved in collagen f...
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15 صفحه اولSmall leucine-rich proteoglycans in kidney disease.
Research over the past 2 decades provides ample evidence that small leucine-rich proteoglycans (SLRPs; such as decorin, biglycan, fibromodulin, and lumican) of the extracellular matrix are deeply involved in the regulation of inflammatory and fibrotic renal disorders. Initial efforts in SLRP research focused on the interaction between decorin and TGF-β because it had been unequivocally demonstr...
متن کاملSmall leucine rich repeat proteoglycans (SLRPs) in the human sclera: identification of abundant levels of PRELP.
PURPOSE The small leucine rich proteoglycan (SLRP) family is made up of several members which are thought to guide matrix assembly and organization through protein:protein and/or protein:carbohydrate interactions. In order to better characterize the composition of the scleral extracellular matrix, gene and protein expression of several members of the SLRP family were evaluated in the human scle...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2008
ISSN: 1063-4584
DOI: 10.1016/s1063-4584(08)60246-0